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CIK 0002022626 · Non-accelerated filer<br>Smaller reporting company<br>Emerging growth company

Upstream Bio, Inc.

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Ticker
UPB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
FY end
Dec 31
Incorporated
DE
Entity type
operating
Phone
781-208-2466
Business address
890 WINTER STREET, SUITE 200, WALTHAM, MA, 02451
Open-market buys, last 90 days
$0
in 0 filings
Open-market sales, last 90 days
$27,604
in 5 filings

Net −$27,604. Shares bought or sold at a price by officers, directors and 10% owners (Form 4 codes P and S). Grants, option exercises and tax withholding aren't counted.

Date Insider Transaction Shares Price Value Owned after
2025-02-06 Deykin Aaron Chief Medical Officer Grant or award · Stock Option (Right to Buy) +165,000 165,000
2025-02-06 Ambrose Allison General Counsel Grant or award · Stock Option (Right to Buy) +25,000 25,000
2024-12-16 Ambrose Allison General Counsel Grant or award · Stock Option (Right to Buy) +100,000 100,000
2024-10-15 AI Upstream LLC 10% owner Purchase 10b5-1 +1,175,000 $17.00 $20.0M 1,175,000
2024-10-15 AI Upstream LLC 10% owner Conversion 10b5-1 +3,147,000 4,322,000
2024-10-15 AI Upstream LLC 10% owner Conversion 10b5-1 +1,172,410 5,494,410
2024-10-15 AI Upstream LLC 10% owner Conversion · Series A Convertible Preferred Stock 10b5-1 −3,147,000 0
2024-10-15 AI Upstream LLC 10% owner Conversion · Series B Convertible Preferred Stock 10b5-1 −1,172,410 0
2024-10-15 Chimovits Erez Director Conversion +721,956 973,716
2024-10-15 Chimovits Erez Director Purchase +165,000 $17.00 $2.8M 1,138,716
2024-10-15 Chimovits Erez Director Conversion +2,887,833 3,894,873
2024-10-15 Chimovits Erez Director Purchase +660,000 $17.00 $11.2M 4,554,873
2024-10-15 Chimovits Erez Director Conversion · Series A redeemable convertible preferred stock −524,500 0
2024-10-15 Chimovits Erez Director Conversion · Series A redeemable convertible preferred stock −2,098,000 0
2024-10-15 Chimovits Erez Director Conversion · Series B redeemable convertible preferred stock −197,456 0
2024-10-15 Chimovits Erez Director Conversion · Series B redeemable convertible preferred stock −789,833 0
2024-10-15 ORBIMED ADVISORS LLC Director Conversion +721,956 973,716
2024-10-15 ORBIMED ADVISORS LLC Director Purchase +165,000 $17.00 $2.8M 1,138,716
2024-10-15 ORBIMED ADVISORS LLC Director Conversion +2,887,833 3,894,873
2024-10-15 ORBIMED ADVISORS LLC Director Purchase +660,000 $17.00 $11.2M 4,554,873

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