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CIK 0002022626 · Non-accelerated filer<br>Smaller reporting company<br>Emerging growth company

Upstream Bio, Inc.

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Ticker
UPB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
FY end
Dec 31
Incorporated
DE
Entity type
operating
Phone
781-208-2466
Business address
890 WINTER STREET, SUITE 200, WALTHAM, MA, 02451
Open-market buys, last 90 days
$0
in 0 filings
Open-market sales, last 90 days
$27,604
in 5 filings

Net −$27,604. Shares bought or sold at a price by officers, directors and 10% owners (Form 4 codes P and S). Grants, option exercises and tax withholding aren't counted.

Pace of trading Bought Sold

Who's trading

90 days

  1. Sutherland Everett Rand −$12K Chief Executive Officer sold 3% of stake
  2. Deykin Aaron −$5K Chief Medical Officer sold 3% of stake
  3. GRAY MICHAEL −$5K CFO and COO sold 3% of stake
  4. Houghton Adam −$4K Chief Business Officer sold 3% of stake
  5. Ambrose Allison −$3K General Counsel sold 3% of stake
Date Insider Transaction Shares Price Value Owned after
2026-03-16 Houghton Adam Chief Business Officer Sale −699 $9.29 $6K 24,301
2026-01-02 GRAY MICHAEL CFO and COO Grant or award +30,500 30,500
2026-01-02 GRAY MICHAEL CFO and COO Grant or award · Stock Option (Right to Buy) +91,500 91,500
2026-01-02 Deykin Aaron Chief Medical Officer Grant or award +32,000 33,581
2026-01-02 Deykin Aaron Chief Medical Officer Grant or award · Stock Option (Right to Buy) +96,000 96,000
2026-01-02 Ambrose Allison General Counsel Grant or award +17,000 17,000
2026-01-02 Ambrose Allison General Counsel Grant or award · Stock Option (Right to Buy) +51,000 51,000
2026-01-02 Houghton Adam Chief Business Officer Grant or award +25,000 25,000
2026-01-02 Houghton Adam Chief Business Officer Grant or award · Stock Option (Right to Buy) +75,000 75,000
2026-01-02 Sutherland Everett Rand Chief Executive Officer Grant or award +75,000 75,000
2026-01-02 Sutherland Everett Rand Chief Executive Officer Grant or award · Stock Option (Right to Buy) +225,000 225,000
2025-06-10 Ruddy Marcella K. Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2025-06-10 Beckman Daniella Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2025-06-10 Renaud Ronald C JR Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2025-06-10 Fleming Harold Edward Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2025-06-10 Chimovits Erez Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2025-06-10 Ratcliffe Liam Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2025-02-06 Sutherland Everett Rand Chief Executive Officer Grant or award · Stock Option (Right to Buy) +500,000 500,000
2025-02-06 GRAY MICHAEL CFO and COO Grant or award · Stock Option (Right to Buy) +195,000 195,000
2025-02-06 Houghton Adam Chief Business Officer Grant or award · Stock Option (Right to Buy) +140,000 140,000

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