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CIK 0002022626 · Non-accelerated filer<br>Smaller reporting company<br>Emerging growth company

Upstream Bio, Inc.

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Ticker
UPB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
FY end
Dec 31
Incorporated
DE
Entity type
operating
Phone
781-208-2466
Business address
890 WINTER STREET, SUITE 200, WALTHAM, MA, 02451
Open-market buys, last 90 days
$0
in 0 filings
Open-market sales, last 90 days
$27,604
in 5 filings

Net −$27,604. Shares bought or sold at a price by officers, directors and 10% owners (Form 4 codes P and S). Grants, option exercises and tax withholding aren't counted.

Pace of trading Bought Sold

Who's trading

90 days

  1. Sutherland Everett Rand −$12K Chief Executive Officer sold 3% of stake
  2. Deykin Aaron −$5K Chief Medical Officer sold 3% of stake
  3. GRAY MICHAEL −$5K CFO and COO sold 3% of stake
  4. Houghton Adam −$4K Chief Business Officer sold 3% of stake
  5. Ambrose Allison −$3K General Counsel sold 3% of stake
Date Insider Transaction Shares Price Value Owned after
2026-09-16 Deykin Aaron Chief Medical Officer Sale −895 $5.49 $5K 32,302
2026-09-16 Sutherland Everett Rand Chief Executive Officer Sale −2,095 $5.49 $12K 68,717
2026-09-16 Houghton Adam Chief Business Officer Sale −700 $5.49 $4K 22,901
2026-09-16 GRAY MICHAEL CFO and COO Sale −853 $5.49 $5K 27,942
2026-09-16 Ambrose Allison General Counsel Sale −485 $5.49 $3K 15,563
2026-06-16 GRAY MICHAEL CFO and COO Sale −853 $6.10 $5K 28,795
2026-06-16 Sutherland Everett Rand Chief Executive Officer Sale −2,095 $6.10 $13K 70,812
2026-06-16 Houghton Adam Chief Business Officer Sale −700 $6.10 $4K 23,601
2026-06-16 Deykin Aaron Chief Medical Officer Sale −895 $6.10 $5K 33,197
2026-06-16 Ambrose Allison General Counsel Sale −477 $6.10 $3K 16,048
2026-06-09 Ruddy Marcella K. Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2026-06-09 Renaud Ronald C JR Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2026-06-09 Fleming Harold Edward Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2026-06-09 Beckman Daniella Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2026-06-09 Ratcliffe Liam Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2026-06-09 Chimovits Erez Director Grant or award · Stock Option (Right to Buy) +17,096 17,096
2026-03-16 GRAY MICHAEL CFO and COO Sale −852 $9.29 $8K 29,648
2026-03-16 Deykin Aaron Chief Medical Officer Sale −894 $9.29 $8K 32,687
2026-03-16 Sutherland Everett Rand Chief Executive Officer Sale −2,093 $9.29 $19K 72,907
2026-03-16 Ambrose Allison General Counsel Sale −475 $9.29 $4K 16,525

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