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CIK 0001636282 · Large accelerated filer

Spyre Therapeutics, Inc.

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Ticker
SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
FY end
Dec 31
Incorporated
DE
Entity type
operating
EIN
464312787
Phone
6176515940
Business address
221 CRESCENT STREET, BUILDING 23, SUITE 105, WALTHAM, MA, 02453
Former names
Aeglea BioTherapeutics, Inc.
Open-market buys, last 90 days
$0
in 0 filings
Open-market sales, last 90 days
$12,349,597
in 6 filings, $12.3M under 10b5-1 plans

Net −$12,349,597. Shares bought or sold at a price by officers, directors and 10% owners (Form 4 codes P and S). Grants, option exercises and tax withholding aren't counted.

Reading 100 more Form 4s from the SEC; this list fills in as they're read.

Date Insider Transaction Shares Price Value Owned after
2026-01-02 Turtle Cameron Chief Executive Officer Sale 10b5-1 −100 $32.39 $3K 671,907
2025-12-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −10,995 $28.73 $316K 690,912
2025-12-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −4,005 $29.83 $119K 686,907
2025-11-03 Turtle Cameron Chief Executive Officer Sale 10b5-1 −28,155 $23.13 $651K 718,752
2025-11-03 Turtle Cameron Chief Executive Officer Sale 10b5-1 −16,845 $23.66 $399K 701,907
2025-09-02 Burrows Scott L Chief Financial Officer Sale −18,428 $16.26 $300K 97,994
2025-05-29 Fairmount Funds Management LLC Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-05-29 Fairmount Funds Management LLC Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-05-29 Stelzer Laurie Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-05-29 Milligan Sandra Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-05-29 McKenna Mark C. Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-05-29 HENDERSON MICHAEL THOMAS Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-05-29 Albers Jeffrey W. Director Grant or award · Stock Option (Right to Buy) +25,000 25,000
2025-01-15 Burrows Scott L Chief Financial Officer Grant or award · Stock Option (Right to Buy) +95,500 95,500
2025-01-15 Sloan Sheldon Chief Medical Officer Grant or award · Stock Option (Right to Buy) +95,500 95,500
2025-01-15 Turtle Cameron Chief Executive Officer Grant or award · Stock Option (Right to Buy) +370,000 370,000
2025-01-15 King-Jones Heidy See Remarks Grant or award · Stock Option (Right to Buy) +95,500 95,500
2025-01-10 HENDERSON MICHAEL THOMAS Director Other acquisition +105,379 105,379
2024-11-06 Albers Jeffrey W. Director Sale 10b5-1 −6,700 $36.76 $246K 27,360
2024-10-25 Albers Jeffrey W. Director Sale 10b5-1 −300 $36.43 $11K 34,060

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