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CIK 0001636282 · Large accelerated filer

Spyre Therapeutics, Inc.

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Ticker
SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
FY end
Dec 31
Incorporated
DE
Entity type
operating
EIN
464312787
Phone
6176515940
Business address
221 CRESCENT STREET, BUILDING 23, SUITE 105, WALTHAM, MA, 02453
Former names
Aeglea BioTherapeutics, Inc.
Open-market buys, last 90 days
$0
in 0 filings
Open-market sales, last 90 days
$12,349,597
in 6 filings, $12.3M under 10b5-1 plans

Net −$12,349,597. Shares bought or sold at a price by officers, directors and 10% owners (Form 4 codes P and S). Grants, option exercises and tax withholding aren't counted.

Reading 100 more Form 4s from the SEC; this list fills in as they're read.

Date Insider Transaction Shares Price Value Owned after
2026-10-01 King-Jones Heidy See Remarks Option exercise 10b5-1 +28,933 $14.50 $420K 31,778
2026-10-01 King-Jones Heidy See Remarks Sale 10b5-1 −400 $89.24 $36K 31,378
2026-10-01 King-Jones Heidy See Remarks Sale 10b5-1 −16,605 $90.35 $1.5M 14,773
2026-10-01 King-Jones Heidy See Remarks Sale 10b5-1 −7,228 $91.35 $660K 7,545
2026-10-01 King-Jones Heidy See Remarks Sale 10b5-1 −2,100 $92.70 $195K 5,445
2026-10-01 King-Jones Heidy See Remarks Sale 10b5-1 −2,600 $93.46 $243K 2,845
2026-10-01 King-Jones Heidy See Remarks Option exercise · Stock Option (Right to Buy) 10b5-1 −28,933 482,478
2026-10-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −600 $89.14 $53K 551,940
2026-10-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −2,683 $90.10 $242K 549,257
2026-10-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −2,638 $91.49 $241K 546,619
2026-10-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −3,989 $92.31 $368K 542,630
2026-10-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −4,990 $93.37 $466K 537,640
2026-10-01 Turtle Cameron Chief Executive Officer Sale 10b5-1 −100 $93.91 $9K 537,540
2026-10-01 Burrows Scott L Chief Financial Officer Option exercise 10b5-1 +7,500 $14.50 $109K 87,262
2026-10-01 Burrows Scott L Chief Financial Officer Sale 10b5-1 −600 $89.07 $53K 86,662
2026-10-01 Burrows Scott L Chief Financial Officer Sale 10b5-1 −1,500 $90.27 $135K 85,162
2026-10-01 Burrows Scott L Chief Financial Officer Sale 10b5-1 −2,100 $91.92 $193K 83,062
2026-10-01 Burrows Scott L Chief Financial Officer Sale 10b5-1 −3,071 $92.95 $285K 79,991
2026-10-01 Burrows Scott L Chief Financial Officer Sale 10b5-1 −229 $93.57 $21K 79,762
2026-10-01 Burrows Scott L Chief Financial Officer Option exercise · Stock Option (Right to Buy) 10b5-1 −7,500 312,357

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